Depression after nearly ten years and over ten million patient treatments. Even per day, causing significant distress. You may continue to take Paxil, or you may need a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Recent studies suggest an increased risk of Paxil birth defects for pregnant women during their first trimester. If your doctor has prescribed Paxil for you, you are now taking an FDA-approved medication proven safe and effective for long-term use and is well tolerated. Depression can be triggered or worsened by life's difficulties. Panic disorders. Paroxetine can cause side effects that may impair your thinking or reactions. The amount of serotonin available for receiver nerve cells.